I-FACTOR Bone Graft products are sterilized after packaging (terminally sterilized), can be stored at room temperature and have a three-year shelf life. I-FACTOR Bone Graft is not a morphogen so, unlike engineered growth factors, the signals sent following P-15 Osteogenic Cell Binding Peptide attachment in a bony site only activate cells that are pre-programmed to become osteoblasts. Being surface-bound, all cellular activity resulting from P-15 Osteogenic Cell Binding Peptide attachment is restricted to the implant surface so bone cannot grow where it doesn’t belong (ectopic bone growth). This unique combination creates a surface-bound “Attract, Attach, Activate” mechanism of action that enhances the body’s natural bone healing process. Lauweryns studied 40 patients undergoing PLIF surgery and assessed their progress using radiographs, CT scans, the Visual Analog Scale (VAS), and Oswestry Disability Index (ODI). I-FACTOR Bone Graft is the only biologic bone graft made of a small peptide, P-15 Osteogenic Cell Binding Peptide, bound to an anorganic bone mineral (ABM). An advanced biologics company with i-FACTOR® Peptide Enhanced Bone Graft powered by P-15 Osteogenic Cell Binding Peptide Cerapedics is an advanced. rhBMP2 (i.e., INFUSE® Bone Graft) when used for spinal fusion procedures other than single-level anterior spinal fusion (e.g., posterior lumbar fusion, transforaminal lumbar fusion, more than single-level fusion) rhBMP2 (i.e. i-FACTOR biologic bone graft features synthetic small peptide (P-15) technology that supports bone growth through cell attachment and osteoblast differentiation. will have access to a biologic bone graft based on our proprietary P-15 technology platform, providing a safe and effective alternative to a. The use of i-FACTOR peptide enhanced bone graft (Cerapedics) resulted in a 50 fusion rate, compared to a 20 fusion rate using allograft in patients with non-instrumented surgery. Now for the first time spine surgeons in the U.S.
2016 14:103.I-FACTOR Bone Graft is an advanced biologic that is supported with level I evidence, satisfies the highest regulatory imperatives, and provides a better cost/benefit ratio than engineered growth factors and cellular allografts. i-FACTOR peptide enhanced bone graft had a 30 higher fusion rate than allograft in patients with non-instrumented surgery. Our lead technology platform (i-FACTOR Peptide Enhanced Bone Graft) is the only biologic bone graft that uses a unique small peptide attachment factor. Bone harvested from a person’s iliac crest is typically used and contains osteoblasts. Here in this post, apart from JCI Insight Impact Factor, I have tried to compile all the necessary information a research scholar would seek before publishing an article in the journal.
Ifactor biologic skin#
The mechanisms of actions of bone grafts fall into three general types: Osteogenesis: The bone graft contains bone-forming cells (osteoblasts). Tech and healthcare giant GE (NYSE:GE) put some skin in Cerapedics and its i-FACTOR bone graft, funding a 9 million venture debt financing round for the Colorado-based company. The role of peptides in bone healing and regeneration: a systematic review. increased emphasis on incorporating biologic therapies in bone-forming grafts. Pountos I, Panteli M, Lampropoulos A, Jones E, Calori GM, and Giannoudis PV. i-FACTOR Biologic Bone Graft novel mechanism of action enhances the bodys natural bone healing process, resulting in safe, predictable bone formation. Visser R, Rico-Llanos GA, Pulkkinen H, and Becerra J. I-FACTOR Bone Graft is an advanced biologic that is supported with level I evidence, satisfies the highest regulatory imperatives, and provides a better cost/benefit ratio than engineered growth factors and cellular (stem cell) allografts.ġ. i-FACTOR provides a mechanism of action that is safe and predictable. Unlike engineered growth factors, i-FACTOR Bone Graft is not a morphogen and, being surface-bound, all cellular activity resulting from P-15 attachment is restricted to the implant surface so bone cannot grow where it doesn’t belong (ectopic bone growth). Ortega B, Gardner C, Roberts S, Chung A, Wang JC, Buser Z. The unique combination creates a surface bound mechanism of action, which provides a microenvironment capable of supporting cell adhesion, proliferation and differentiation that enhances the body’s natural bone healing process. Ceramic Biologics for Bony Fusion-a Journey from First to Third Generations. The novel bone enhancing biologic i-FACTOR is not only cost-effective but may represent a dominant economic strategy, affording greater benefit at lower. I-FACTOR Peptide Enhanced Bone Graft is the only osteobiologic that combines a small bioactive peptide, P-15, which replicates the cell-binding domain of human type I collagen, with an anorganic bone mineral (ABM). i-FACTOR Biologic Bone Graft is the only bone graft that combines a unique anorganic bone mineral (ABM) and small peptide (P-15) to act as an attachment.
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